Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. II. Structure elucidation of terpendoles A, B, C and D.
نویسندگان
چکیده
Structures of terpendoles A, B, C and D, novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors, were determined by spectroscopic studies. All terpendoles consist of diterpene and indole moieties in common. Terpendoles A, C and D possess an additional isoprenyl unit via oxygen atom(s) of their diterpene moieties. The relative stereochemistries of terpendoles C and D were confirmed by NOE experiments and X-ray crystallographic analysis.
منابع مشابه
A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5.
To reveal the mechanism of mitosis, the development of M phase-specific inhibitors is an important strategy. We have been screening microbial products to find specific M phase inhibitors that do not directly target tubulins, and rediscovered terpendole E (TerE) as a novel Eg5 inhibitor. TerE did not affect microtubule integrity in interphase, but induced formation of a monoastral spindle in M p...
متن کاملDetection of oxygen addition peaks for terpendole E and related indole–diterpene alkaloids in a positive-mode ESI-MS
This report describes that a regular positive electrospray ionization mass spectrometry (MS) analysis of terpendoles often causes unexpected oxygen additions to form [M + H + O](+) and [M + H + 2O](+), which might be a troublesome in the characterization of new natural analogues. The intensities of [M + H + O](+) and [M + H + 2O](+) among terpendoles were unpredictable and fluctuated largely. S...
متن کاملMicrobial metabolites affecting lipid biosynt hesis
Microbial inhibitors for two enzymes involved in lipid metabolism, acylCoA:cholesterol acyltransferase (ACAT) and famesyl-protein transferase (FTase), were screened with assay systems using partially purified enzymes. ACAT inhibitors are expected to work as cholesterol-lowering or anti-atherosclerotic agents, and FTase inhibitors are as anticancer drugs. Three kinds of new ACAT inhibitors were ...
متن کاملStructure elucidation and chemistry of novel diterpenoids from Euphorbia plants of Iran
Plants of the genus Euphorbia have been investigated for different bioactive natural products. I have isolated several new and bioactive diterpenoids from different species of Euphorbia of Iran with myrsinane type skeleton. The structure of the compounds was determined using high resolution mass spectroscopy, 1 D and 2 D NMR spectral data. The stereochemistry of the diterpenoids was determined ...
متن کاملStructure elucidation and chemistry of novel diterpenoids from Euphorbia plants of Iran
Plants of the genus Euphorbia have been investigated for different bioactive natural products. I have isolated several new and bioactive diterpenoids from different species of Euphorbia of Iran with myrsinane type skeleton. The structure of the compounds was determined using high resolution mass spectroscopy, 1 D and 2 D NMR spectral data. The stereochemistry of the diterpenoids was determined ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 48 1 شماره
صفحات -
تاریخ انتشار 1995